Mechanism of Blood Coagulation

The Mechanism of the Action of Saliva in Blood Coagulation

It is well known that the addition of saliva to blood will accelerate its coagulation (1, 2, 7). This property of saliva is not species specific. It has been shown that dog, cat and human saliva will indiscriminately accelerate the clotting of blood obtained from the dog, cat, cow or man (1, 7). Bellis, Birnbaum and Scott (1) noted that while the clotting factor of saliva was stable at 60 " , i...

Mechanism of factor VIIa-dependent coagulation in hemophilia blood.

The ability of factor VIIa to initiate thrombin generation and clot formation in blood from healthy donors, blood from patients with hemophilia A, and in anti-factor IX antibody-induced ("acquired") hemophilia B blood was investigated. In normal blood, both factor VIIa-tissue factor (TF) complex and factor VIIa alone initiated thrombin generation. The efficiency of factor VIIa was about 0.0001 ...

The adsorption of coagulation factors onto phospholipids. Its role in the reaction mechanism of blood coagulation.

Lages coagulation mechanism in blood obtained from bleeding time wounds

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Blood Coagulation

INTRODUCTION This section covers the means, as far as we now know them, by which components of the blood plasma produce an insoluble protein meshwork, or gel, at a site of blood-vessel damage. The plasma is normally completely fluid, containing all its proteins in soluble form. When the clotting system is activated at a site of blood-vessel damage, a series of proteolytic reactions is set going...